[ZKKL] Academic Presentation | Recent Advances in the Classification and Treatment of Lymphomatoid Papulosis

1. 1 A Type and B Type 1982 Willemze Wait for the… Ly P Divided into A Type and B Type. A The histopathological type is the most common; it is characterized by wedge-shaped infiltrates composed of scattered or clustered atypical anaplastic large cells intermixed with small lymphocytes, neutrophils, and eosinophils. Because the tumor cells resemble histiocytes in morphology, this subtype was also referred to as the histiocytic type in earlier literature. B This type is a rare subtype, characterized by involvement of the dermis. CD4 Positive small to medium-sized pleomorphic cells show wedge-shaped infiltration or band-like epidermotropic infiltration; the tumor cells resemble gyral lymphocytes seen in mycosis fungoides.

1. 2 C Type 1993 Willemze Cases that initially present clinically as necrotic papules or nodules, yet exhibit pathological features resembling anaplastic large-cell lymphoma, are defined as a new entity. Ly P Subtype. Its clinical features are consistent with classic lymphomatoid papulosis, but the pathology reveals patchy infiltration of atypical large cells within the dermis, resembling cutaneous anaplastic large-cell lymphoma.

1. 3 D Type 2010 Saggini Wait for the report. 9  Example patients, whose clinical characteristics are consistent with… Ly P Consistent with an inert biological behavior. However, the pathological findings demonstrate a marked tropism for the epidermis. CD8+ Lymphocytic infiltration, with small to medium-sized lymphocytes, resembling the primary cutaneous invasive epidermotropic type. CD8 The pathology of positive cytotoxic lymphoma is similar, but the tumor cells exhibit varying degrees of expression. CD30 Marking. In China, Xiong Jingshu and Wen Pengfei, among others, have reported similar cases. 2012  year Kempf Wait until the report is submitted. 13  In cases similar to this patient, the authors, however, diagnosed it as expression. CD30 Acute pityriasis lichenoides et varioliformis acuta ( Acute pityriasis lichenoides et varioliformis acuta ， PLEVA) . Recent research has found that approximately 1 /3 of children Ly P All patients had previously suffered from… PLEVA Alternatively, it may be chronic lichenoid pityriasis. To date, more than… have been reported. 15  For example, in patients with lichenoid pityriasis, lesions have been found to contain… CD30 + Cellular infiltration, and the study found that in some cases… PLEVA A monoclonal population can be detected. T Cells. These findings suggest that D Type Ly P With and PLEVA An absolute distinction between them is not possible; the two may be considered a spectrum of disorders.

1. 4 E Type 2012 Kempf Wait until the first report was filed. 16  Example And E Type Ly P The patient typically presents with solitary or a few scattered papules that rapidly progress to larger ulcers, accompanied by hemorrhagic necrosis and eschar-like changes; in some cases, the lesions may reach a diameter of up to… 4cm Pathologically, there is angiotropic infiltration by pleomorphic lymphocytes; in some patients, vascular destruction may be observed, and intravascular thrombi may also occur.

1. 5 F Type Namely, follicular-type Ly P. 1980  year Pierard Wait until the first report was filed. 2  In this case, papules and nodules occur intermittently at the hair follicles or around ruptured follicles. Histopathologically, there is infiltration of atypical lymphocytes and inflammatory cells in the superficial dermis surrounding the hair follicles, with multinucleated R cells occasionally observed. Eed-Sternberg Sample cell. Kempf Wait until it becomes follicular. Ly P The characteristics are summarized as :  Within the hair follicle and around the hair follicle CD30 + Cellular infiltration, cyst wall distension, follicular rupture, proliferation of follicular epithelium, and neutrophil accumulation within the follicular epithelium. However, some studies have also reported findings across various types. Ly P The perifollicular phenomenon can be observed in all cases; therefore, it is perifollicular in nature. Ly P Whether it constitutes an independent subtype remains debatable.

1. 6 6p25. 3 Chromosomal rearrangement type 2013 Karai Wait until the first report was filed. 11  For example, histologically it manifests as a biphasic growth pattern. Ly P . This type of case is characterized by two distinct types of neoplastic cells: the superficial component consists of cerebriform small lymphocytes with epidermotropic behavior, which within the epidermis exhibit a pattern resembling Pagetoid reticulosis; the deep component comprises larger, anaplastic lymphocytes that proliferate in sheets and nodular patterns. The neoplastic cells express CD30 , in which the staining intensity of superficial small tumor cells is weaker than that of deep-seated large tumor cells. A distinctive molecular biological feature of such cases is chromosomal alterations in the tumor cells. 6p25. 3 on the DUSP22-I R F4 Gene rearrangement. Some scholars believe that 6p25. 3 The rearrangement leads to DUSP22 Its expression is reduced, thereby attenuating its tumor-suppressive effects and potentially contributing to tumorigenesis.